after 6 months return back to my blog..


Red wine can help fight cavities


Researchers have said that red wine could help ward off dental diseases with fewer side effects.

M. Victoria Moreno-Arribas and colleagues explain that dental diseases are extremely common throughout the world. Cavities, periodontal disease and tooth loss affect an estimated 60 to 90 per cent of the global population.

The problems start when certain bacteria in the mouth get together and form biofilms, which are communities of bacteria that are difficult to kill. They form plaque and produce acid, which starts damaging teeth.


Smallest, fastest nanomotor moves drugs and releases them on demand



Mobility is an important function of any drug-delivering robot–even a well-designed machine that ultimately can’t get where it’s needed serves little to no purpose. To this end, researchers have developed a wide range of innovative devices from microrockets to DNA propellers to sperm-driven robots.

Read more: Smallest, fastest nanomotor moves drugs and releases them on demand – FierceDrugDelivery
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Phosphagenics’ animal health topical patch shows promise


TPM/Oxycodone topical patch to combat neuropathic pain in large companion animals relieved all racehorses within two days in an initial study, the company said May 21.

The Australian company focuses on developing topical gels using its targeted penetration matrix delivery technology based on vitamin E phosphate. Earlier this year, the system was used by Novartis ($NVS) to launch a topical gel in India designed to treat pain associated with osteoarthritis, rheumatism and associated injuries.

Read more: Phosphagenics’ animal health topical patch shows promise – FierceDrugDelivery
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Scientists find new way to mobilize immune system against viruses

Scientists find new way to mobilize immune system against viruses.

Cardamom: Courage in a Bottle

Cardamom: Courage in a Bottle.

Timely post on litigation and polymorphism: Case study with Celgene’s Revlimid

Developing the Process

Hi there, folks.  It has been a while since I blogged.  I decided that I would continue once again and share some of the references that I came across while perusing the journals, while using the free blog-hosting services that are available.  This particular post was something I came across while looking at some stocks online.  I was searching taking a look at Celgene (CELG) stock and came across this discussion regarding the tricky world of patent litigation and more specifically, its application to matters concerning crystal form and polymorphism.  Having worked both sides of generic and brand-name pharma, I am interested in how this case will work out.

I know that this article’s subject matter is on the periphery of what is involved in developing a process.  I have worked on crystallizations and been concerned with polymorph control, so this is a textbook case, that is current, about patent…

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Deprotection with water ? Really.

Developing the Process

Occasionally,  I have reservations about posting some of the articles I present.  Sometimes,  they may not be too practical,  I don’t endorse it as an article that you should try to scale-up.  But I get excited about these findings and want to share, especially when there is a green, environmental angle.  I am trying to suggest some articles that are worth looking at.  Having written a bit of a disclaimer,  I thought this was a neat paper using water at elevated temperatures.  Although this was done on small scale, could it be used for industrial scale ?  I was thinking that using water at high temperature would have require enormous heating and cooling requirements. You would have to test the chemical stability of your substrate when using WET (water at elevated temperatures).   It, still, is an interesting read (at least to me).  What seems really neat is the ability to tune…

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Chlorination with convenience: Palau’chlor

Developing the Process

I came across this article in JACS recently.  I remember using chlorine gas myself and being a little trepidacious with it.  It is a nasty gas to deal with.  I had to remember to clean out the regulator after every use so it didn’t corrode and make it difficult to close at the most inopportune time.  I used thionyl chloride a lot and that had a tendency to wreak havoc on my Rotovap at the time.  Not nice stuff.  Anyways.

What caught my eye with this article was that it was written by Phil Baran at Scripps and Martin Eastgate at Bristol-Myers Squibb in Chem. Dev., so it was worth a gander to take a look and see if this paper was a keeper for later use.  The article I am referring to is “Palau’chlor: A Practical and Reactive Chlorinating Reagent”, by Phil S. Baran et al, J. Am. Chem…

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Error at IBM Lab Finds New Family of Materials

As a research chemist at an IBM laboratory, Jeannette M. Garcia spends her days mixing and heating chemicals in pursuit of stronger and more easily recyclable plastics. Recently she followed a simple formula that required mixing three components in a beaker. Somehow she missed a step, leaving out a chemical. She returned to find her beaker filled with a hard white plastic that had even frozen the stirrer.

Dr. Garcia tried grinding the mystery material, to no avail. Then she took a hammer to the beaker to free it.

That laboratory error has led to the discovery of a new family of materials that are unusually strong and light, exhibit “self-healing” properties and can be easily reformed to make products recyclable.

The materials — two new types of synthetic polymers — could have transportation uses. Because of their recyclability, they also could have an impact on consumer products, as well as on the industrial packaging for microelectronics components.

The findings were reported on Thursday in the journal Science by a research

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